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Principal Investigator
Andrew H. J. Wang
Post Doctors
Ph.D. Students
Assistants
Alumni
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王惠鈞
Andrew H.-J. Wang
Email: ahjwang@gate.sinica.edu.tw
Tel: +886-2-2785-5696 ext. 4060
Fax: +886-2-2788-2043
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| Education |
| 1974 |
Ph.D., University of Illinois at Urbana-Champaign. |
| 1970 |
M.S. , National Taiwan University. |
| 1967 |
B.S., National Taiwan University. |
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| Positions |
| 2006-2011 |
present Distinguished Research Fellow and Vice President (Academic), Academia Sinica |
| 2000-2006 |
Distinguished Research Fellow and Director, Institute of Biological Chemistry, Academia Sinica |
| 1996-1997 |
Acting Head, Dept. of Cell & Structural Biology, UIUC |
| 1988-2000 |
Professor of Biophysics, Biochemistry, and Chemistry, Dept. of Cell & Structural Biology, Biochemistry, UIUC |
| 2/95-5/95 |
Visiting Professor, Department of Biophysical Chem., Nijmegen University
(with Prof. C. Hilbers) |
| 9/87-2/88 |
Visiting Associate, Division of Chemistry, Caltech (with Prof. P. B. Dervan) |
| 1-7/81 & 3-4/83 |
Visiting Scientist, Gorlaeus Lab., Leiden State Univ., The Netherlands (with Prof. J. H. van Boom) |
| 1974-1988 |
Postdoctoral Research Associate (74-80), Research Scientist (80-82),
Principal Research Scientist (82-85), Senior Research Scientist (85-88), Department of Biology, MIT |
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| Other Professional Activities |
| 2011-present |
President, the Federation of Asian and Oceanian Biochemists and Molecular Biologists (FAOBMB) |
| 2009-present |
President, The K-T Wang Bioorganic Chemistry Foundation |
| 2007-present |
Distinguished Research Chair Professor, National Taiwan University |
| 2007-2011 |
Director-in-Chief, National Research Program for Genomic Medicine (A US$30 millions national program) |
| 2006-present |
Chair Professor, National Chung Hsing University |
| 2006-present |
Council Member, Taiwan Proteomics Society |
| 2004-present |
Council Member, Taiwan Society of Biochemistry and Molecular Biology |
| 2003-present |
Council Member, Human Proteomic Organization (HUPO) |
| 2003-2006 |
Council Member, AOHUPO |
| 2003-2006 |
President, Taiwan Proteomics Society |
| 2002-present |
Adj. Distinguished Research Fellow, Institute of Mol. Biol., Taipei, Taiwan |
| 2001-2007 |
President, Biophysics Society of ROC |
| 2001-2004 |
President, Taiwan Society of Biochemistry and Molecular Biology |
| 1998-2002 |
Editorial Board, Nucleic Acids Research |
| 1995-2002 |
Editor, European J. Biochem. |
| 1993-1996 |
Member, NSF Predoctoral Fellowship Review Panel |
| 1992-2002 |
Adj. Research Fellow, Institute of Mol. Biol., Taipei, Taiwan |
| 1991-1994 |
Member, NIH BBCA Study Section |
| 1990-1993 |
Member, Advisory Board, Biotechnology Center, UIUC |
| 1988-1996 |
Member, Advisory Board, Institute of Mol. Biol., Taipei, Taiwan |
| 1987-present |
Member, Oversea Advisory Board, Newton Graphic Science Magazine (Taiwan) |
| 1984-1994 |
Member, Organizing Committee for the SUNYA Conversation in the Discipline of Biomolecular Stereodynamics |
| 1984 |
Director, Second Summer School in Biophysics, International Center for Theoretical Physics, Trieste, Italy |
| 1983-1994 |
Member, Editorial Board, J. Biomol. Struct. Dyn. |
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| Membership & Honors |
| 2010 |
Distinguished Achievement Award, Chinese Institute of Engineers/USA-Great New York Chapter |
| 2009 |
National Innovation and Invention Award, Ministry of Economic Affairs, Taiwan, ROCN |
| 2007 |
Science and Engineering Achievement Award, Taiwanese-American Foundation |
| 2007 |
Fellow, A-IMBN |
| 2005 |
Fellow, The Third World Academy of Sciences (TWAS) |
| 2000 |
Academician, Academia Sinica |
| 1998 |
Fellow, American Association for the Advancement of Science |
| 1987 |
Fellow, American Institute of Chemists |
| 1987 |
Elected member, American Society for Biochemistry & Molecular Biology |
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| United States Patent |
- Crystal structure of soluble glutaminyl cyclase (Patent No. 7,892,771)
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| Research Interests |
- Structural proteomics, anticancer drugs, x-ray crystallography, NMR and molecular design.
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- Structural enzymology: Several enzymes as potential targets for drug discovery are under investigation. For developing new antibiotics, we focus on prenyltransferases and glyco-related enzymes. For anti-viral and anticancer agents, we analyze proteases (3CL proteases, MMPs), and phosphatases (DuSPs in signal transduction). Studies of potential targets for diabetics and Alzeheimer's disease are also in progress.
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- Protein- & anticancer drug-DNA interactions: Some DNA-binding proteins (like chromosomal proteins and proteins involved in meiosis) and many important anticancer drugs with DNA are of interest. The results can be useful for the design of new anticancer agents.
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- Search for disease markers: Proteomic approaches, including 2D-GE and nanoLC, mass spectrometry and bioinformatics, are used to analyze cells and tissues from certain diseases to identify potential marker proteins. We are particularly interested in serum samples.
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- Proteins from extreme environments: Microorganisms that live in extreme environments including extreme heat, cold, pH (acidic or alkaline) or radiation resistance have unusual proteins. Some enzymes described above are from those organisms.
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